:root{--font-size-xs: .75rem;--font-size-sm: .875rem;--font-size-base: 1rem;--font-size-md: 1.125rem;--font-size-lg: 1.25rem;--font-size-xl: 1.5rem;--font-size-2xl: 1.875rem;--font-size-3xl: 2.25rem;--font-weight-light: 300;--font-weight-regular: 400;--font-weight-medium: 500;--font-weight-semibold: 600;--font-weight-bold: 700;--line-height-tight: 1.25;--line-height-normal: 1.5;--line-height-relaxed: 1.75;--letter-spacing-tight: -.025em;--letter-spacing-normal: 0;--letter-spacing-wide: .025em;--letter-spacing-wider: .05em}body{font-family:Plus Jakarta Sans,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica,Arial,sans-serif;font-size:var(--font-size-base);line-height:var(--line-height-normal);font-weight:var(--font-weight-regular)}.text-xs{font-size:var(--font-size-xs)}.text-sm{font-size:var(--font-size-sm)}.text-base{font-size:var(--font-size-base)}.text-md{font-size:var(--font-size-md)}.text-lg{font-size:var(--font-size-lg)}.text-xl{font-size:var(--font-size-xl)}.text-2xl{font-size:var(--font-size-2xl)}.text-3xl{font-size:var(--font-size-3xl)}.font-light{font-weight:var(--font-weight-light)}.font-regular{font-weight:var(--font-weight-regular)}.font-medium{font-weight:var(--font-weight-medium)}.font-semibold{font-weight:var(--font-weight-semibold)}.font-bold{font-weight:var(--font-weight-bold)}.leading-tight{line-height:var(--line-height-tight)}.leading-normal{line-height:var(--line-height-normal)}.leading-relaxed{line-height:var(--line-height-relaxed)}.tracking-tight{letter-spacing:var(--letter-spacing-tight)}.tracking-normal{letter-spacing:var(--letter-spacing-normal)}.tracking-wide{letter-spacing:var(--letter-spacing-wide)}.tracking-wider{letter-spacing:var(--letter-spacing-wider)}h1,.h1{font-size:var(--font-size-3xl);font-weight:var(--font-weight-bold);line-height:var(--line-height-tight);letter-spacing:var(--letter-spacing-tight)}h2,.h2{font-size:var(--font-size-2xl);font-weight:var(--font-weight-semibold);line-height:var(--line-height-tight);letter-spacing:var(--letter-spacing-tight)}h3,.h3{font-size:var(--font-size-xl);font-weight:var(--font-weight-semibold);line-height:var(--line-height-tight)}h4,.h4{font-size:var(--font-size-lg);font-weight:var(--font-weight-medium);line-height:var(--line-height-normal)}h5,.h5{font-size:var(--font-size-md);font-weight:var(--font-weight-medium);line-height:var(--line-height-normal)}h6,.h6{font-size:var(--font-size-base);font-weight:var(--font-weight-medium);line-height:var(--line-height-normal)}p{font-size:var(--font-size-base);line-height:var(--line-height-relaxed);margin-bottom:1rem}small,.small{font-size:var(--font-size-sm)}.caption{font-size:var(--font-size-xs);letter-spacing:var(--letter-spacing-wide)}.btn{font-family:Plus Jakarta Sans,sans-serif;font-weight:var(--font-weight-medium);letter-spacing:var(--letter-spacing-wide)}input,select,textarea{font-family:Plus Jakarta Sans,sans-serif;font-size:var(--font-size-base)}.navbar-brand{font-size:var(--font-size-xl);font-weight:var(--font-weight-bold);letter-spacing:var(--letter-spacing-tight)}.control-circle .control-label{font-size:var(--font-size-xs);font-weight:var(--font-weight-medium);text-transform:uppercase;letter-spacing:var(--letter-spacing-wider)}@media (max-width: 768px){:root{--font-size-3xl: 2rem;--font-size-2xl: 1.75rem;--font-size-xl: 1.375rem;--font-size-lg: 1.125rem}}body,html{margin:0;padding:0;width:100%;height:100%;overflow:hidden;background:#000}#visualization{position:fixed;top:0;left:0;width:100vw;height:100vh;z-index:1;overflow:hidden}#controls{position:fixed;top:80px;left:20px;width:auto;min-width:auto;max-height:calc(100vh - 100px);padding:10px;box-sizing:border-box;overflow-y:visible;z-index:3;display:flex;flex-direction:column;gap:15px}.control-circle{width:60px;height:60px;border-radius:50%;display:flex;flex-direction:column;align-items:center;justify-content:center;cursor:pointer;position:relative;transition:all .3s ease;box-shadow:0 4px 8px #0003;background-color:#1e1e23b3;border:1px solid rgba(255,255,255,.1);margin-bottom:10px;pointer-events:auto}.control-circle:hover{transform:translateY(-2px);box-shadow:0 6px 12px #0000004d;background-color:#28282dcc}.control-circle .control-icon{font-size:24px;line-height:1;margin-bottom:2px}.control-circle .control-label{font-size:var(--font-size-xs);font-weight:var(--font-weight-medium);text-transform:uppercase;letter-spacing:var(--letter-spacing-wider);color:#ffffffe6}.control-circle .control-content{position:absolute;left:70px;top:0;width:320px;background:#19191ed9;-webkit-backdrop-filter:blur(10px);backdrop-filter:blur(10px);border-radius:15px;padding:15px;display:none;box-shadow:0 5px 15px #0000004d;z-index:10;pointer-events:auto;border:1px solid rgba(255,255,255,.1);color:#ffffffe6;max-height:calc(100vh - 150px);overflow-y:auto;font-family:Plus Jakarta Sans,sans-serif}.control-circle .control-content h3{font-size:var(--font-size-lg);font-weight:var(--font-weight-semibold);margin-bottom:1rem;letter-spacing:var(--letter-spacing-tight)}.control-content .control-item{margin-bottom:1rem;font-size:var(--font-size-sm)}.control-circle.active{background-color:#4169e180;box-shadow:0 0 15px #4169e180;border-color:#6496ff80;z-index:100}.control-circle.active .control-content{display:block!important;animation:fadeIn .2s ease-out;z-index:101}@keyframes fadeIn{0%{opacity:0;transform:translate(-10px)}to{opacity:1;transform:translate(0)}}#overlay-container{position:fixed;top:0;left:0;width:100vw;height:100vh;pointer-events:none;z-index:2}#zstack-bar{position:fixed;left:50%;bottom:2vw;width:clamp(350px,60vw,1900px);transform:translate(-50%);padding:.7em 1em;border-radius:16px;pointer-events:auto;display:flex;align-items:center;justify-content:center;gap:1em;z-index:1001;color:#fff}#zstack-bar label{margin:0 8px 0 0;font-size:1.1em}#zstack-bar input[type=range]{width:80%;margin:0 12px}.control-group{margin-bottom:20px;padding:15px;border-radius:15px}.control-group h3{margin-top:0;margin-bottom:15px;font-size:16px;color:#ffffffe6;font-weight:500;letter-spacing:.5px}.control-item{margin-bottom:10px}label{display:block;margin-bottom:5px;color:#fffc;font-size:14px}input[type=text],select{width:100%;padding:8px;background:#0003;border:1px solid rgba(255,255,255,.2);border-radius:8px;color:#fff;font-size:14px}input[type=text]::placeholder{color:#ffffff80}button{background:#ffffff1a;border:1px solid rgba(255,255,255,.2);color:#fff;padding:8px 16px;border-radius:8px;cursor:pointer;transition:all .2s ease}button:hover{background:#fff3}select,button{padding:5px;margin:5px 0}.glass{background:#0003;backdrop-filter:blur(15px);-webkit-backdrop-filter:blur(15px);border:1px solid rgba(255,255,255,.3);box-shadow:0 25px 23px #00000026,inset 0 1px #ffffff80,inset 0 -1px #ffffff1a,inset 0 0 4px 2px #fff3;color:#fff}.glass-light{background:#ffffff1a;backdrop-filter:blur(6px);-webkit-backdrop-filter:blur(6px);border:1px solid rgba(255,255,255,.3);box-shadow:0 8px 32px #0000001a,inset 0 1px #ffffff80,inset 0 -1px #ffffff1a;color:#fff}.glass-dark{background:#0000004d;backdrop-filter:blur(15px);-webkit-backdrop-filter:blur(15px);border:1px solid rgba(255,255,255,.1);box-shadow:0 8px 32px #0003,inset 0 1px #ffffff1a;color:#fff}#navbar{position:fixed;top:0;left:0;right:0;height:60px;display:flex;align-items:center;justify-content:space-between;padding:0 20px;z-index:100;font-family:Plus Jakarta Sans,sans-serif;pointer-events:auto}.navbar-controls{display:flex;align-items:center;gap:10px;margin-right:20px;pointer-events:auto}.navbar-controls select{background:#0003;border:1px solid rgba(255,255,255,.2);color:#fff;padding:8px 36px 8px 12px;border-radius:6px;width:200px;font-size:14px;-webkit-appearance:none;-moz-appearance:none;appearance:none;background-image:url("data:image/svg+xml;charset=UTF-8,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 24 24' fill='white'%3e%3cpath d='M7 10l5 5 5-5z'/%3e%3c/svg%3e");background-repeat:no-repeat;background-position:right 12px center;background-size:16px}.navbar-brand{color:#fff;font-size:24px;font-weight:700;letter-spacing:1px;text-shadow:0 2px 4px rgba(0,0,0,.3);pointer-events:auto;-webkit-user-select:text;user-select:text}.gene-checkbox-list{max-height:300px;overflow-x:hidden;border-radius:4px;padding:5px;margin-bottom:10px;display:flex;flex-direction:column}.gene-checkbox-item{display:flex;align-items:center;border-radius:4px;transition:all .2s ease;cursor:pointer;margin-bottom:2px;-webkit-user-select:none;user-select:none;width:auto;padding:1px 2px}.gene-checkbox-item:hover{background-color:#fff3;transform:translate(2px)}.gene-checkbox-item.selected{border-left:1px solid #ddd;padding-left:7px}.gene-checkbox-item label{margin:0;padding-left:5px;cursor:pointer;flex:1;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.gene-color-indicator{display:inline-block;width:12px;height:12px;border-radius:50%;margin-left:5px;box-shadow:0 0 3px #0000004d}#gene-search{width:100%;padding:5px;margin-bottom:10px;border:1px solid #ddd;border-radius:4px}.form-range{background:transparent}.form-range::-webkit-slider-runnable-track{background:#ffffff1a;border:1px solid rgba(255,255,255,.1);border-radius:4px;height:4px}.form-range::-webkit-slider-thumb{background:#fff;border:none;box-shadow:0 0 10px #0000004d;margin-top:-6px;width:16px;height:16px}.form-range::-moz-range-track{background:#ffffff1a;border:1px solid rgba(255,255,255,.1);border-radius:4px;height:4px}.form-range::-moz-range-thumb{background:#fff;border:none;box-shadow:0 0 10px #0000004d;width:16px;height:16px}.form-range:focus::-webkit-slider-thumb{box-shadow:0 0 0 1px #fff3,0 0 10px #0000004d}.form-range:focus::-moz-range-thumb{box-shadow:0 0 0 1px #fff3,0 0 10px #0000004d}#active-genes-container{position:fixed;top:70px;right:20px;width:300px;border-radius:15px;padding:12px;z-index:90;transition:opacity .3s ease,transform .3s ease;pointer-events:auto}#active-genes-container.empty{opacity:0;transform:translateY(-10px);pointer-events:none}.active-genes-header{margin-bottom:8px;padding-bottom:6px;border-bottom:1px solid rgba(255,255,255,.2);text-align:center;font-weight:600}.active-genes-container{padding:10px;max-height:300px;overflow-y:auto;display:flex;flex-wrap:wrap;gap:8px;border-radius:10px}@media (max-width: 600px){#active-genes-container{width:200px;right:10px}}.active-gene-item{display:flex;align-items:center;padding:6px 12px;border-radius:20px;border:1px solid rgba(33,150,243,.4);position:relative;min-width:0;margin-bottom:4px;transition:all .2s ease;cursor:pointer;animation:geneItemAppear .3s ease-out;pointer-events:auto;-webkit-user-select:none;user-select:none;box-shadow:0 1px 3px #0000001a}@keyframes geneItemAppear{0%{opacity:0;transform:translate(20px)}to{opacity:1;transform:translate(0)}}.active-gene-item:hover{background-color:#2196f340;border-color:#2196f399;transform:translateY(-2px);box-shadow:0 3px 6px #00000026}.active-gene-item:active{transform:translateY(0);box-shadow:0 1px 2px #0003}.active-gene-color{width:14px;height:14px;border-radius:50%;margin-right:8px;box-shadow:0 0 4px #0000004d}.active-gene-name{flex:1;font-weight:600;font-size:.9rem;letter-spacing:.01em}.active-gene-remove{cursor:pointer;color:#fff9;font-size:16px;padding:0 5px;transition:all .2s ease;display:flex;align-items:center;justify-content:center;width:20px;height:20px;border-radius:50%}.active-gene-remove:hover{color:#f44336;background-color:#ffffff1a}.empty-message{color:#fff9;text-align:center;padding:10px;width:100%}#gene-selector{display:flex;align-items:center}#gene-select{flex:1;margin-right:10px}.stats{font-size:12px;color:#666}.stats p{margin:5px 0}canvas{display:block}.tooltip,#hover-window{position:absolute;pointer-events:none;z-index:1000;background:#000c;color:#fff;padding:10px;border-radius:5px;font-family:Arial,sans-serif;max-width:200px;transition:opacity .2s ease}#tooltip-container{position:absolute;pointer-events:none;z-index:1000}.tooltip,#hover-window.hidden{opacity:0}.tooltip.visible,#hover-window.visible{opacity:1}.tooltip-content,.hover-content{margin:0;padding:0}.tooltip h3{margin:0 0 5px;font-size:14px}.tooltip p{margin:0;padding:0;font-size:12px}.tooltip span{font-weight:700}.customize-tooltip{display:none;position:absolute;z-index:2000;width:250px;animation:tooltipFadeIn .2s;overflow:hidden;border-radius:12px;box-shadow:0 10px 25px #0000004d}@keyframes tooltipFadeIn{0%{opacity:0;transform:translateY(5px)}to{opacity:1;transform:translateY(0)}}.customize-tooltip-header{padding:8px 12px;display:flex;justify-content:space-between;align-items:center}#customize-gene-name{font-weight:700;font-size:var(--font-size-lg)}.close-tooltip{font-size:18px;font-weight:700;cursor:pointer;opacity:.6}.close-tooltip:hover{opacity:1}.customize-tooltip-body{padding:12px}.customize-option{margin-bottom:12px}.customize-option:last-child{margin-bottom:0}.customize-option label{display:block;margin-bottom:6px;font-weight:700;font-size:13px}.customize-option input[type=color]{width:100%;height:30px;border-radius:4px;cursor:pointer}.customize-option input[type=range]{width:100%;margin:5px 0}.customize-tooltip-footer{padding:8px 12px;text-align:right}#reset-gene-customization{padding:5px 10px;border-radius:4px;cursor:pointer;font-size:12px;opacity:.8}#reset-gene-customization:hover{opacity:1}